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598 Aktuelle Fachpublikationen in Letters in Organic Chemistry

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Facile Utilisation of Aldehyde Bisulfite Adducts: Synthesis of (E)-1,2- Diphenylethenes

18.05.2017 | Vinay P.Kumar, K.; Jaganmohan, C.; Sandeep Reddy, G.; Mohanty, Sandeep; Kumar, Jaydeep; Rao, Venkateswara, Letters in Organic Chemistry, 2017

Abstract: Background: A one-pot coupling reaction of aldehyde bisulfite adducts was developed for McMurry reaction using Zn-TiCl4 in 1,4-dioxane solvent medium. The treatment of sodium hydroxy( phenyl)methane sulfonate (2a) with TiCl4 in 1,4-dioxane favoured the deprotection of the ...

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A One-Pot Approach for the Preparation of Novel Anil-Like Compounds from 2,3-Dihydroxynaphthalene

18.05.2017 | Sadeghpour, Mahdieh; Mohammadgoliha, Mahbubeh, Letters in Organic Chemistry, 2017

Abstract: Background: A series of novel anil-like compounds was constructed via a three-component domino condensation of 2,3-dihydroxynaphthalene, triethylorthoformate and heteroaryl amines in the presence of formic acid catalyst under solvent-free conditions. Significant features of this ...

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Microwave-Promoted One-Pot Three-Component Synthesis of 1-Amidoalkyl-2-Carbazolol Derivatives

18.05.2017 | Padmaja, Pannala; Narayana Reddy, Pedavenkatagari, Letters in Organic Chemistry, 2017

Abstract: Background: 1,3-Aminooxygenated functional groups exhibit a variety of biological and pharmacological activities including nucleosides, antibiotics and HIV protease inhibitors. On the other hand, carbazole-containing molecules show antiviral, antimalarial and antitumor activity. ...

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Synthesis and Structural Determination of Novel Fluorinated Steroidal Spiro(pyrazolo[4,3-e][1,2,4]triazin-3′-yl) Derivatives as Affecting Enzymatic Agents

18.05.2017 | Bakhotmah, Dina; Abdel-Rahman, Reda, Letters in Organic Chemistry, 2017

Abstract: Background: Spiro(pyrazolo[4,3-e][1,2,4]triazin-3′-yl) derivatives are key building blocks of many pharmaceuticals, agrochemicals and biologically active compounds. Fluorinated compounds have a remarkable record in medicinal chemistry and provide lead compounds for ...

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Computer Assisted Design and Synthesis of Novel Chiral Piperazine Derivatives from 3-Hydroxynopinone

02.05.2017 | Jagan Mohan Reddy, Boggu; Kumar Konreddy, Ananda; Usha Rani, Grandhe; Rambabu, G.; Prudhvi Raju, N.; Anjibabu, R.; G ..., Letters in Organic Chemistry, 2017

Abstract: Background: Hepatitis C virus (HCV) Flaviviridae family comprises of positive sense singlestranded RNA ((+)ssRNA), which infects 3% of the world population that leads to the liver cirrhosis. There is no permanent cure available without side effects till date. Many drug discovery ...

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Synthesis of N2-glycosylated Dihydropyrimidones – A Novel Approach Using Epoxy Sugar

02.05.2017 | R. Subimol, K.; Arul Antony, S., Letters in Organic Chemistry, 2017

Abstract: Background: A novel route towards synthesis of N-glycosylated dihydropyrimidones (DHPMs) using epoxy sugar has been described. The DHPM derivatives were synthesised from aromatic aldehydes, urea/thiourea and ethyl acetoacetate in presence of CuCl and BF3.OEt2. The reported ...

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A Short Route to the Ester (±) HomoSarkomycin via Johnson-Claisen Rearrangement

02.05.2017 | Saied, Mαhamed; Gatri, Rafik; Sulaiman Al-Ayed, Abdullah; Arfaoui, Youssef; Moncef El Gaied, Mohamed, Letters in Organic Chemistry, 2017

Abstract: Background: α-Methylene cycloalkanones are considered of interest because of their biological activity. Herein, in this paper the synthesis of (±) HomoSarkomycine Esters was described and characterized. Methods: Using Bylis-Hillman adducts, triethlorthoacetate and propanoic acid, (±) ...

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Nanoparticles of Organosilane-based NaHSO4 Ionic Liquid Immobilized on Silica as Reusable Heterogeneous Catalyst for One-pot Synthesis of 2-oxo-and thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidines

02.05.2017 | Abri, Abdolreza; Ghasemian khojasteh, Mohsen, Letters in Organic Chemistry, 2017

Abstract: Background: In spite of the fact that there are numerous reagents and methods to synthesize the dihydropyrimidinones via Biginelli reaction, but excellent yields, shorter reaction time and easy work-up are important factors which are not usually found together in a chemical ...

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Introduction of an Effective and Economical Heterogeneous Ruthenium Catalyst for Regioselective Ring-Opening of Epoxides and the Friedel– Crafts Alkylation Reaction of Indoles and Pyrroles

02.05.2017 | Tabatabaeian, Khalil; Ali Zanjanchi, Mohammad; O. Mahmoodi, Nosrat.; Eftekhari, Tooraj, Letters in Organic Chemistry, 2017

Abstract: Background: Metal organic frameworks square measure crystalline materials with fascinating chemical and physical attributes that include metal ions or clusters and multidentate organic particles. MOFs acquire the expected traits to be employed in classical applications similar to ...

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Theoretical Study of 1,3-Dipolar Reactions of Myrcene and Trimethylsilylazide

02.05.2017 | Taban, Sepehr; Arman Taherpour, Avat, Letters in Organic Chemistry, 2017

Abstract: Background: Triazoline derivatives are important group of the heterocycle compounds possessing interesting medicinal and biological properties. Triazoline compounds can be applied in medicine because of their pharmaceutical properties as antiviral, antibacterial, anti-cancerous, ...

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